Therapy Detail

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Therapy Name Sipuleucel-T
Synonyms
Therapy Description

Provenge (sipuleucel-T) is composed of autologous dendritic cells exposed to a PAP-GCSF fusion protein (PA2024), which stimulates a cytotoxic immune response towards PAP-expressing tumor cells (PMID: 25565923, PMID: 25708576). Provenge (sipuleucel-T) is FDA-approved for use in patients with metastatic castration-resistant prostate cancer (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Sipuleucel-T Provenge APC 8015 Provenge (sipuleucel-T) is composed of autologous dendritic cells exposed to a PAP-GCSF fusion protein (PA2024), which stimulates a cytotoxic immune response towards PAP-expressing tumor cells (PMID: 25565923, PMID: 25708576). Provenge (sipuleucel-T) is FDA-approved for use in patients with metastatic castration-resistant prostate cancer (FDA.gov).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01818986 Phase II Sipuleucel-T Sipuleucel-T and Stereotactic Ablative Body Radiation (SABR) for Metastatic Castrate-resistant Prostate Cancer (mCRPC) Completed USA 0
NCT01560923 Phase II Sipuleucel-T Phase II Study of Sipuleucel-T and Indoximod for Patients With Refractory Metastatic Prostate Cancer Completed USA 0
NCT01706458 Phase II pTVG-HP plasmid DNA vaccine Sipuleucel-T Provenge With or Without pTVG-HP DNA Booster Vaccine in Prostate Cancer Completed USA 0
NCT02463799 Phase II Radium Ra 223 dichloride Sipuleucel-T Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC Completed USA 0
NCT02036918 Phase I Sipuleucel-T Dendreon Lymph Node Biopsy in Metastatic Castrate-Resistant Prostate Cancer Completed USA 0
NCT02353715 Phase I Abiraterone Enzalutamide Sipuleucel-T Men With Metastatic Castrate-Resistant Prostate Cancer Treated With Either Sipuleucel-T (Provenge), Abiraterone Acetate (Zytiga) or Enzalutamide (Xtandi) Undergoing Cardiopulmonary EXercise Testing Completed USA 0
NCT03686683 Phase III Sipuleucel-T Open- Label Trial of Sipuleucel-T Administered to Active Surveillance Patients for Newly Diagnosed Prostate Cancer (ProVent) Active, not recruiting USA 0
NCT05806814 Phase I Sipuleucel-T Sipuleucel-T Based Autologous Cellular Immunotherapy for Advanced Prostate Cancer Recruiting USA 0
NCT05751941 Phase II Sipuleucel-T Abiraterone + Sipuleucel-T Apalutamide + Sipuleucel-T Enzalutamide + Sipuleucel-T Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer Recruiting USA 0
NCT01807065 Phase II Sipuleucel-T Sipuleucel-T With or Without Radiation Therapy in Treating Patients With Hormone-Resistant Metastatic Prostate Cancer Completed USA 0
NCT02159950 Phase II Sipuleucel-T Tasquinimod Sipuleucel-T With or Without Tasquinimod in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Completed USA 0


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