Therapy Detail

Therapy Name radium Ra 223 dichloride
Therapy Description

Radium Ra 223 dichloride is a radium-based radiopharmaceutical that targets bone via incorporation into bony matrix, and results in DNA double strand breaks and tumor regression in bone (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
radium Ra 223 dichloride Xofigo BAY 88-8223|alpharadin Radium Ra 223 dichloride is a radium-based radiopharmaceutical that targets bone via incorporation into bony matrix, and results in DNA double strand breaks and tumor regression in bone (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT02258464 Phase II radium Ra 223 dichloride Study of Radium-223 Dichloride Versus Placebo and Hormonal Treatment as Background Therapy in Subjects With Bone Predominant HER2 (Human Epidermal Growth Factor Receptor 2) Negative Hormone Receptor Positive Metastatic Breast Cancer Active, not recruiting
NCT02258451 Phase II Exemestane + Everolimus radium Ra 223 dichloride Study of Radium-223 Dichloride Versus Placebo and Treatment With Exemestane / Everolimus in Subjects With Bone Predominant HER2 (Human Epidermal Growth Factor Receptor 2) Negative Hormone Receptor Positive Metastatic Breast Cancer Active, not recruiting
NCT02507570 Phase II Enzalutamide radium Ra 223 dichloride Open Label Phase Two Study of Enzalutamide With Concurrent Administration of Radium Ra 223 Dichloride in Castration-Resistant (Hormone-Refractory) Prostate Cancer Subjects With Symptomatic Bone Metastasis Active, not recruiting
NCT02463799 Phase II radium Ra 223 dichloride Sipuleucel-T Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC Active, not recruiting
NCT02605356 Phase Ib/II radium Ra 223 dichloride Bortezomib Dexamethasone Phase 1b/2 Study Testing Radium-223 Dichloride/Bortezomib/Dexamethasone Combination in Relapsed Multiple Myeloma Withdrawn
NCT02406521 Phase I Pazopanib radium Ra 223 dichloride Sorafenib Exploratory Study of Radium-223 and Vascular Endothelial Growth Factor-Targeted Therapy in Patients With Metastatic Renal Cell Carcinoma and Bone Metastases Active, not recruiting
NCT03093428 Phase II Pembrolizumab + Ra 223 radium Ra 223 dichloride Study Evaluating the Addition of Pembrolizumab to Radium-223 in mCRPC Recruiting
NCT02366130 Phase II radium Ra 223 dichloride Denosumab Phase II Trial of Ra-223 Dichloride and Hormonal Treatment Active, not recruiting
NCT02396368 Phase I Tasquinimod radium Ra 223 dichloride A Study of Radium-223 in Combination With Tasquinimod in Bone-only Metastatic Castration-Resistant Prostate Cancer Withdrawn
NCT02034552 Phase II Prednisone radium Ra 223 dichloride Enzalutamide Abiraterone A Randomized Phase IIa Efficacy and Safety Study of Radium-223 Dichloride With Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (CRPC) Completed
NCT02043678 Phase III Prednisone Abiraterone radium Ra 223 dichloride Radium-223 Dichloride and Abiraterone Acetate Compared to Placebo and Abiraterone Acetate for Men With Cancer of the Prostate When Medical or Surgical Castration Does Not Work and When the Cancer Has Spread to the Bone, Has Not Been Treated With Chemotherapy and is Causing no or Only Mild Symptoms Active, not recruiting