Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|VE-821||VE821||ATR Inhibitor 12||VE-821 is a small molecule inhibitor of ATR, which may inhibit cell growth and enhance the sensitivity of chemotherapeutics (PMID: 22825331, PMID: 32354033).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ARID1A Q456*||colorectal cancer||sensitive||VE-821||Preclinical - Cell culture||Actionable||In a preclinical study, colorectal cancer cells homozygous for ARID1A Q456* were sensitive to VE-821 in in vitro assays, demonstrating decrease cell survival (PMID: 27958275).||27958275|
|ARID1A mutant||ovarian clear cell carcinoma||sensitive||VE-821||Preclinical - Cell culture||Actionable||In a preclinical study, ovarian clear cell carcinoma cells harboring an ARID1A mutation were sensitive to VE-821 in in vitro assays, demonstrating decreased cell survival (PMID: 27958275).||27958275|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|