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Therapy Name | AZ20 |
Synonyms | |
Therapy Description |
AZ20 is a small molecule inhibitor of ATR, which may inhibit tumor growth and induce cell death (Cancer Res April 15, 2012 72; 1823). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
AZ20 | AZ 20|AZ-20 | ATR Inhibitor 13 | AZ20 is a small molecule inhibitor of ATR, which may inhibit tumor growth and induce cell death (Cancer Res April 15, 2012 72; 1823, PMID: 23394205). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A - MLLT1 NRAS G12D | acute myeloid leukemia | predicted - sensitive | AZ20 | Preclinical | Actionable | In a preclinical study, AZ20 treatment resulted in growth inhibition of tumor cells and prolonged survival in animal models of acute myeloid leukemia harboring KMT2A-MLLT1 fusion and NRAS G12D (PMID: 27625305). | 27625305 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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