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AZ20 is a small molecule inhibitor of ATR, which may inhibit tumor growth and induce cell death (Cancer Res April 15, 2012 72; 1823).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AZ20||AZ 20|AZ-20||ATR Inhibitor 14||AZ20 is a small molecule inhibitor of ATR, which may inhibit tumor growth and induce cell death (Cancer Res April 15, 2012 72; 1823, PMID: 23394205).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KMT2A - MLLT1 NRAS G12D||acute myeloid leukemia||predicted - sensitive||AZ20||Preclinical||Actionable||In a preclinical study, AZ20 treatment resulted in growth inhibition of tumor cells and prolonged survival in animal models of acute myeloid leukemia harboring KMT2A-MLLT1 fusion and NRAS G12D (PMID: 27625305).||27625305|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|