Therapy Detail

Therapy Name Niclosamide
Synonym
Therapy Description

Niclosamide inhibits Wnt signaling, potentially resulting in decreased tumor growth (PMID: 21531761).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Niclosamide Niclocide CTNNB1 Inhibitor 26 Niclosamide inhibits Wnt signaling, potentially resulting in decreased tumor growth (PMID: 21531761).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC inact mut colorectal cancer sensitive Niclosamide Preclinical Actionable In a preclinical study, Niclosamide inhibited proliferation of colorectal cancer cells harboring APC mutations in culture (PMID: 21531761). 21531761
Clinical Trial Phase Therapies Title Recruitment Status
NCT02687009 Phase I Niclosamide A Study of Niclosamide in Patients With Resectable Colon Cancer Recruiting
NCT02532114 Phase I Enzalutamide Niclosamide Niclosamide and Enzalutamide in Treating Patients With Androgen Receptor Splice Variant-Positive, Castration-Resistant, Metastatic Prostate Cancer Completed