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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|SP600125||JNK Inhibitor 4 MPS1 Inhibitor 25||SP600125 is an ATP-competitive inhibitor of JNK, with activity against JNK1, JNK2, and JNK3 and also TTK (Mps1), which may lead to cell-cycle inhibition and decreased growth of tumor cells (PMID: 19478553, PMID: 11717429, PMID: 16113653, PMID: 32835935).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|TP53 loss||colon carcinoma||sensitive||SP600125||Preclinical||Actionable||In a preclinical study, SP600125 induced cell death in colon carcinoma cells deficient for p53 (PMID: 22438244).||22438244|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|