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SP600125 is an ATP-competitive inhibitor of JNK, with activity against JNK1, JNK2, and JNK3 and also TTK (Mps1), which may lead to cell-cycle inhibition and decreased growth of tumor cells (PMID: 19478553, PMID: 11717429, PMID: 16113653).
|DrugClasses||JNK Inhibitor 4 MPS1 Inhibitor 25|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cetuximab + SP600125||Cetuximab SP600125||1||0|
|Paclitaxel + SP600125||Paclitaxel SP600125||0||0|