Drug Detail


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Drug Name SP600125
Trade Name
Drug Descriptions

SP600125 is an ATP-competitive inhibitor of JNK, with activity against JNK1, JNK2, and JNK3 and also TTK (Mps1), which may lead to cell-cycle inhibition and decreased growth of tumor cells (PMID: 19478553, PMID: 11717429, PMID: 16113653, PMID: 32835935).

DrugClasses JNK Inhibitor 5 MPS1 Inhibitor 27
CAS Registry Number 129-56-6


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + SP600125 Cetuximab SP600125 0 0
Paclitaxel + SP600125 Paclitaxel SP600125 0 0
SP600125 SP600125 1 0

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