Therapy Detail

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Therapy Name APTO-253
Synonyms
Therapy Description

APTO-253 is a small molecule that induces expression of KLF4 and CDKN1A, resulting in decreased tumor cell proliferation, cell-cycle arrest, and apoptosis, and has been shown to induce DNA damage (PMID: 26268924, PMID: 29626127, PMID: 29626126).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
APTO-253 APTO-253 is a small molecule that induces expression of KLF4 and CDKN1A, resulting in decreased tumor cell proliferation, cell-cycle arrest, and apoptosis, and has been shown to induce DNA damage (PMID: 26268924, PMID: 29626127, PMID: 29626126).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown lymphoma not applicable APTO-253 Preclinical - Cell culture Actionable In a preclinical study, APTO-253 treatment in acute myeloid leukemia cell lines resulted in decreased proliferation in culture (PMID: 29626127). 29626127
Unknown unknown Advanced Solid Tumor not applicable APTO-253 Phase I Actionable In a Phase I clinical trial, APTO-253 demonstrated safety and resulted in stable disease in 24% (5/32) of evaluable solid tumor patients (PMID: 26268924). 26268924
Unknown unknown acute myeloid leukemia not applicable APTO-253 Preclinical - Cell culture Actionable In a preclinical study, APTO-253 treatment in acute myeloid leukemia cell lines resulted in decreased proliferation, cell-cycle arrest, and induced apoptosis in culture (PMID: 29626127). 29626127

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02267863 Phase I APTO-253 A Study of APTO-253 in Patients With Relapsed or Refractory AML or MDS Recruiting


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