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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|ETC-159||ETC-1922159||WNT Inhibitor 10||ETC-159 is a small molecule inhibitor of PORCN, which is demonstrated to suppress Wnt signaling and may result in inhibition of cell growth and lead to upregulation of genes related to cell differentiation (PMID: 26257057).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||ETC-159||Phase I||Actionable||In a Phase I trial, treatment with ETC-159 was well-tolerated, decreased Wnt signaling, and resulted in stable disease in 2 out of 16 treated patients with advanced solid tumors (J Clin Oncol 35, 2017 (suppl; abstr 2584)).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02521844||Phase I||ETC-159||A Study to Evaluate the Safety and Tolerability of ETC-1922159 in Advanced Solid Tumours||Active, not recruiting|