Therapy Detail

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Therapy Name Tamatinib
Synonyms
Therapy Description

Tamatinib (R406) inhibits SYK, resulting in decreased downstream signaling and and potentially leading to reduced tumor cell proliferation and viability (PMID: 16946104, PMID: 26251761, PMID: 30668583).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tamatinib R406|R-406 SYK Inhibitor 15 Tamatinib (R406) inhibits SYK, resulting in decreased downstream signaling and and potentially leading to reduced tumor cell proliferation and viability (PMID: 16946104, PMID: 26251761, PMID: 30668583).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 D835K FLT3 D835L hematologic cancer no benefit Tamatinib Preclinical - Cell culture Actionable In a preclinical study, Tamatinib (R406) did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 I836S hematologic cancer no benefit Tamatinib Preclinical - Cell culture Actionable In a preclinical study, Tamatinib (R406) did not inhibit viability of transformed cells expressing FLT3 I836S in culture (PMID: 28077790). 28077790
FLT3 Q575del hematologic cancer sensitive Tamatinib Preclinical - Cell culture Actionable In a preclinical study, Tamatinib (R406) decreased proliferation in transformed cells expressing FLT3 Q575del in culture (PMID: 33914060). 33914060
FLT3 D835A hematologic cancer no benefit Tamatinib Preclinical - Cell culture Actionable In a preclinical study, Tamatinib (R406) did not inhibit viability of transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 I836D FLT3 I836L hematologic cancer no benefit Tamatinib Preclinical - Cell culture Actionable In a preclinical study, Tamatinib (R406) did not inhibit viability of transformed cells expressing FLT3 I836D and I836L in culture (PMID: 28077790). 28077790

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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