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Therapy Name Tebentafusp
Synonyms
Therapy Description

Kimmtrak (tebentafusp) is a gp100 antigen-specific human T-cell receptor (TCR) linked to an anti-CD3 antibody fragment, which activates cytotoxic immune response against gp100-expressing tumor cells (PMID: 24531387, PMID: 31336704, PMID: 32816891). Kimmtrak (tebentafusp) is FDA approved for use in HLA-A*2:01-positive metastatic or unresectable uveal melanoma patients.

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tebentafusp Kimmtrak ImmTAC-gp100|Tebentafusp-tebn|IMCgp100 Kimmtrak (tebentafusp) is a gp100 antigen-specific human T-cell receptor (TCR) linked to an anti-CD3 antibody fragment, which activates cytotoxic immune response against gp100-expressing tumor cells (PMID: 24531387, PMID: 31336704, PMID: 32816891). Kimmtrak (tebentafusp) is FDA approved for use in HLA-A*2:01-positive metastatic or unresectable uveal melanoma patients.

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02889861 Phase Ib/II Tebentafusp IMCgp100-401 Rollover Study Terminated USA | GBR 0
NCT02570308 Phase I Tebentafusp A Study of the Intra-Patient Escalation Dosing Regimen With IMCgp100 in Patients With Advanced Uveal Melanoma Completed USA | GBR | ESP | DEU | CAN 0
NCT03070392 Phase II Dacarbazine Ipilimumab Pembrolizumab Tebentafusp Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma Active, not recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 5
NCT05315258 Phase II Tebentafusp Tebentafusp in Molecular Relapsed Disease (MRD) Melanoma (TebeMRD) Recruiting GBR 0
NCT02535078 Phase Ib/II Durvalumab Tebentafusp Tremelimumab Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Cutaneous Melanoma Completed USA 0
NCT06070012 Phase II Tebentafusp Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma Not yet recruiting USA 0
NCT05549297 Phase II Pembrolizumab + Tebentafusp Tebentafusp Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM) Recruiting USA | ITA | GBR | FRA | ESP | DEU | BEL | AUT | AUS 2


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