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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|UM-164||p38 MAPK Inhibitor (Pan) 4 SRC Inhibitor 29||UM-164 is a small molecule that binds to a specific inactive conformation of Src, resulting in inhibition of Src downstream signaling and inhibits p38 MAPKs, resulting in growth inhibition, and apoptosis in tumor cells (PMID: 27154914, PMID: 29282631, PMID: 28463369).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|SRC positive||triple-receptor negative breast cancer||predicted - sensitive||UM-164||Preclinical - Cell line xenograft||Actionable||In a preclinical study, UM-164 inhibited proliferation and induced apoptosis in human triple-receptor negative breast cancer cell lines with elevated Src activity in culture, and inhibited tumor growth in cell line xenograft models (PMID: 27154914).||27154914|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|