Therapy Detail

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Therapy Name Trastuzumab Duocarmazine
Synonyms
Therapy Description

SYD985 is an antibody-drug conjugate consisting of the Erbb2 (Her2)-targeting antibody trastuzumab bound to a derivative of the cytotoxic drug duocarmycin, which results in increased death of Erbb2 (Her2)-expressing tumor cells (PMID: 27256376).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Trastuzumab Duocarmazine SYD985|SYD-985|Trastuzumab vc-seco-DUBA|SYD 985 HER2 (ERBB2) Antibody 37 Trastuzumab Duocarmazine (SYD985) is an antibody-drug conjugate consisting of the Erbb2 (Her2)-targeting antibody trastuzumab bound to a derivative of the cytotoxic drug duocarmycin, which results in increased death of Erbb2 (Her2)-expressing tumor cells (PMID: 27256376).

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 positive uterine corpus serous adenocarcinoma sensitive Trastuzumab Duocarmazine Preclinical - Cell line xenograft Actionable In a preclinical study, Trastuzumab Duocarmazine (SYD895) induced cell death in ERBB2 (HER2)-expressing primary uterine serous carcinoma (USC) cell lines in culture, including cell lines with both high and low levels of ERBB2 (HER2) expression, and inhibited tumor growth and improved survival in ERBB2 (HER2)-expressing USC primary cell line xenografts (PMID: 27256376). 27256376
ERBB2 amp uterine corpus serous adenocarcinoma sensitive Trastuzumab Duocarmazine Preclinical Actionable In a preclinical study, Trastuzumab Duocarmazine (SYD895) induced cell death in ERBB2 (HER2)-amplified primary uterine serous carcinoma (USC) cell lines in culture and inhibited tumor growth and improved survival in ERBB2 (HER2)-amplified USC primary cell line xenografts (PMID: 27256376). 27256376
ERBB2 positive breast cancer predicted - sensitive Trastuzumab Duocarmazine Phase I Actionable In a Phase I trial, Trastuzumab Duocarmazine (SYD985) treatment resulted in an overall response of 33% (33/99) and a median progression-free survival of 9.4 months in patients with ERBB2 (HER2)-positive (50) or ERBB2 (HER2)-low (49) metastatic breast cancer (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 1014-1014; NCT02277717). detail...
ERBB2 positive ovarian carcinoma sensitive Trastuzumab Duocarmazine Preclinical - Cell culture Actionable In a preclinical study, Trastuzumab Duocarmazine (SYD985) decreased survival of a ERBB2 (HER2)-positive ovarian carcinoma cell line in culture (PMID: 25589493). 25589493
ERBB2 positive breast carcinoma sensitive Trastuzumab Duocarmazine Preclinical - Pdx & cell culture Actionable In a preclinical study, Trastuzumab Duocarmazine (SYD985) decreased survival of ERBB2 (HER2)-positive breast carcinoma cell lines in culture, and inhibited tumor growth and induced tumor remission in cell line and patient-derived xenograft models of ERBB2 (HER2)-positive breast carcinoma, including models with low ERBB2 (HER2) expression (PMID: 25589493). 25589493
ERBB2 positive stomach carcinoma sensitive Trastuzumab Duocarmazine Preclinical - Cell culture Actionable In a preclinical study, Trastuzumab Duocarmazine (SYD985) decreased survival of a ERBB2 (HER2)-positive gastric carcinoma cell line in culture (PMID: 25589493). 25589493

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Clinical Trial Phase Therapies Title Recruitment Status
NCT04205630 Phase II Trastuzumab Duocarmazine SYD985 in Patients With HER2-expressing Recurrent, Advanced or Metastatic Endometrial Carcinoma Recruiting
NCT03262935 Phase III Capecitabine + Lapatinib Trastuzumab Duocarmazine Eribulin + Trastuzumab Capecitabine + Trastuzumab Trastuzumab + Vinorelbine SYD985 vs. Physician's Choice in Participants With HER2-positive Locally Advanced or Metastatic Breast Cancer (TULIP) Recruiting


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