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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|LF3||CTNNB1 Inhibitor 26||LF3 is a small molecule that inhibits the interaction between beta-catenin (CTNNB1) and TCF, resulting in reduced Wnt target gene expression, decreased migration of tumor cells, and potentially resulting in decreased tumor growth (PMID: 26645562, PMID: 29786110).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||colon cancer||not applicable||LF3||Preclinical - Cell line xenograft||Actionable||In a preclinical study, LF3 decreased expression of Wnt target genes and reduced tumor growth in colon cancer cell line xenograft models derived from cells with high levels of Wnt signaling (PMID: 26645562).||26645562|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|