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|Therapy Name||AZD8055 + SBI-0206965|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AZD8055||AZD-8055||mTOR Inhibitor 51 PI3K Inhibitor (Pan) 38||AZD8055 is a PI3K/MTOR inhibitor that reduces downstream signaling, resulting in decreased tumor cell growth (PMID: 20028854, PMID: 31519159).|
|SBI-0206965||SBI-0206965 is a small molecule that selectively inhibits ULK1, resulting in decreased phosphorylation of ULK1 targets, and potentially leading to increased tumor cell death in combination with mTOR inhibitors (PMID: 26118643, PMID: 30166400, PMID: 32393312).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||lung non-small cell carcinoma||not applicable||AZD8055 + SBI-0206965||Preclinical - Cell culture||Actionable||In a preclinical study, the addition of SBI-0206965 to treatment with AZD8055 resulted in increased apoptosis in a non-small cell lung cancer cell line in culture (PMID: 26118643).||26118643|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|