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|Therapy Name||unspecified CTLA4 antibody|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|unspecified CTLA4 antibody||experimental CTLA4 antibody|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|POLE mutant||Advanced Solid Tumor||predicted - sensitive||unspecified CTLA4 antibody||Clinical Study - Cohort||Actionable||In a clinical study, immune checkpoint inhibitor (ICI) treatment, including CTLA4, PD-1, and PD-L1-targeting antibodies, resulted in prolonged overall survival (34 vs 18 months, p=0.004) in patients with advanced solid tumors harboring POLE or POLD1 mutations compared to wild-type patients, and POLE/POLD1 mutation served as a predictor of response to ICI (p=0.047, HR=1.41) independent of MSI-H status (PMID: 31415061).||31415061|
|CTNNB1 act mut||hepatocellular carcinoma||decreased response||unspecified CTLA4 antibody||Clinical Study - Cohort||Actionable||In a clinical study, treatment with immune checkpoint antibodies, including anti-PD-1, anti-PD-L1, or anti-CTLA-4 monotherapy or combinations of anti-PD-1 with anti-CTLA-4, anti-LAG3, or anti-KIR, was less effective in patients with Wnt pathway mutations in CTNNB1 or AXIN1 compared to patients without mutations in this pathway, with 0% (0/10) vs. 53% (9/17) achieving disease control, respectively, and shorter progression-free survival (2.0 months vs. 7.4 months) (PMID: 30373752; NCT01775072).||30373752|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02843165||Phase II||unspecified PD-L1 antibody unspecified CTLA4 antibody unspecified PD-1 antibody||Checkpoint Blockade Immunotherapy Combined With Stereotactic Body Radiation in Advanced Metastatic Disease||Recruiting|