Therapy Detail

Therapy Name AK-01
Synonyms
Therapy Description

AK-01 selectively inhibits Aurka, which may result in tumor growth inhibition (AACR Annual Meeting 2019, Abstract CT019).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AK-01 LY3295668 erbumine Aurka Inhibitors 23 AK-01 selectively inhibits Aurka, which may result in tumor growth inhibition (AACR Annual Meeting 2019, Abstract CT019).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable AK-01 Phase I Emerging In a Phase I trial, AK-01 demonstrated desirable pharmacokinetics in patients with locally advanced or metastatic solid tumors (AACR Annual Meeting 2019, Abstract CT019; NCT03092934). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT03955939 Phase I AK-01 + Midazolam AK-01 A Study of LY3295668 Erbumine in Participants With Breast Cancer That Has Spread to Other Parts of the Body Not yet recruiting
NCT03898791 Phase Ib/II AK-01 A Study of LY3295668 Erbumine in Participants With Extensive-stage Small-Cell Lung Cancer Not yet recruiting
NCT03092934 Phase Ib/II AK-01 A Study of AK-01 (LY3295668) in Solid Tumors Active, not recruiting


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