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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|KU60648||KU-0060648||DNA_PK Inhibitor 6||KU60648 is a DNA protein kinase inhibitor, which may lead to impairment of double stranded break repair, thereby resulting in decreased cell viability (PMID: 28224663).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|MLH1 loss||colon cancer||sensitive||KU60648||Preclinical - Cell culture||Actionable||In a preclinical study, MLH1 deficient colon cancer cell lines were sensitive to KU60648 in culture, demonstrating decreased cell viability and reduced colony formation (PMID: 28224663).||28224663|
|MSH6 loss||colon cancer||no benefit||KU60648||Preclinical - Cell culture||Actionable||In a preclinical study, MSH6 deficient colon cancer cells did not respond to treatment with KU60648 in culture (PMID: 28224663).||28224663|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|