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Therapy Name | G-TPP + Obatoclax |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
G-TPP | Gamitrinib-TPP | G-TPP is a Gamitrinib variant that inhibits mitochondrial Hsp90, which induces tumor cell death (PMID: 23147571, PMID: 32664214). | ||
Obatoclax | GX015-070 | BCL2 Family Inhibitor 6 | Obatoclax (GX015-070) is a pan-BCL2 family inhibitor, which leads to induction of tumor cell apoptosis (PMID: 18040043, PMID: 17332241, PMID: 32367199). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | melanoma | not applicable | G-TPP + Obatoclax | Preclinical - Cell culture | Actionable | In a preclinical study, the mitochondrial Hsp90 inhibitor G-TPP and the broad BH3 mimetic Obatoclax (GX015-070) synergistically inhibited viability of established melanoma cells in culture (PMID: 28522750). | 28522750 |
Unknown unknown | pancreatic cancer | not applicable | G-TPP + Obatoclax | Preclinical - Cell culture | Actionable | In a preclinical study, the mitochondrial Hsp90 inhibitor G-TPP and the broad BH3 mimetic Obatoclax (GX015-070) synergistically inhibited viability of pancreatic cancer cells in culture (PMID: 28522750). | 28522750 |
Unknown unknown | glioblastoma | not applicable | G-TPP + Obatoclax | Preclinical - Patient cell culture | Actionable | In a preclinical study, the mitochondrial Hsp90 inhibitor G-TPP and the broad BH3 mimetic Obatoclax (GX015-070) synergistically inhibited viability of established lines and patient-derived glioblastoma cells in culture (PMID: 28522750). | 28522750 |
Unknown unknown | triple-receptor negative breast cancer | not applicable | G-TPP + Obatoclax | Preclinical - Cell culture | Actionable | In a preclinical study, the mitochondrial Hsp90 inhibitor G-TPP and the broad BH3 mimetic Obatoclax (GX015-070) synergistically inhibited viability of triple-receptor negative breast cancer cells in culture (PMID: 28522750). | 28522750 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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