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Therapy Name | GNE-272 |
Synonyms | |
Therapy Description |
GNE-272 is an inhibitor targeting the bromodomains of CREBBP and EP300, which subsequently prevents MYC expression, thereby potentially resulting in anti-proliferative effects and tumor growth inhibition (PMID: 27682507). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
GNE-272 | GNE-272 is an inhibitor targeting the bromodomains of CREBBP and EP300, which subsequently prevents MYC expression, thereby potentially resulting in anti-proliferative effects and tumor growth inhibition (PMID: 27682507). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Unknown unknown | multiple myeloma | not applicable | GNE-272 | Preclinical - Cell culture | Actionable | In a preclinical study, GNE-272 treatment resulted in anti-proliferative activity in multiple myeloma cell lines in culture (PMID: 27682507). | 27682507 |
Unknown unknown | acute myeloid leukemia | not applicable | GNE-272 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with GNE-272 in acute myeloid leukemia xenograft models resulted in tumor growth inhibition at all doses, and at the highest dose led to a complete response in one of the eight tested mouse models (PMID: 27682507). | 27682507 |
Unknown unknown | lymphoma | not applicable | GNE-272 | Preclinical - Cell culture | Actionable | In a preclinical study, GNE-272 treatment resulted in anti-proliferative activity in lymphoma cell lines in culture (PMID: 27682507). | 27682507 |
Unknown unknown | leukemia | not applicable | GNE-272 | Preclinical - Cell culture | Actionable | In a preclinical study, GNE-272 treatment resulted in anti-proliferative activity in leukemia cell lines in culture (PMID: 27682507). | 27682507 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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