Therapy Detail
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| Therapy Name | GNE-272 |
| Synonyms | |
| Therapy Description |
GNE-272 is an inhibitor targeting the bromodomains of CREBBP and EP300, which subsequently prevents MYC expression, thereby potentially resulting in anti-proliferative effects and tumor growth inhibition (PMID: 27682507). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GNE-272 | GNE-272 is an inhibitor targeting the bromodomains of CREBBP and EP300, which subsequently prevents MYC expression, thereby potentially resulting in anti-proliferative effects and tumor growth inhibition (PMID: 27682507). |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| Unknown unknown | multiple myeloma | not applicable | GNE-272 | Preclinical - Cell culture | Actionable | In a preclinical study, GNE-272 treatment resulted in anti-proliferative activity in multiple myeloma cell lines in culture (PMID: 27682507). | 27682507 |
| Unknown unknown | acute myeloid leukemia | not applicable | GNE-272 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with GNE-272 in acute myeloid leukemia xenograft models resulted in tumor growth inhibition at all doses, and at the highest dose led to a complete response in one of the eight tested mouse models (PMID: 27682507). | 27682507 |
| Unknown unknown | lymphoma | not applicable | GNE-272 | Preclinical - Cell culture | Actionable | In a preclinical study, GNE-272 treatment resulted in anti-proliferative activity in lymphoma cell lines in culture (PMID: 27682507). | 27682507 |
| Unknown unknown | leukemia | not applicable | GNE-272 | Preclinical - Cell culture | Actionable | In a preclinical study, GNE-272 treatment resulted in anti-proliferative activity in leukemia cell lines in culture (PMID: 27682507). | 27682507 |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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