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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Barasertib||AZD1152|AZD-1152||Aurkb Inhibitors 18||Barasertib (AZD1152) is a selective Aurora B kinase inhibitor, which induces cell cycle arrest (PMID: 17495131, PMID: 30540594).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||acute myeloid leukemia||not applicable||Barasertib||Phase II||Actionable||In a Phase II trial, Barasertib (AZD1152) treatment resulted in significantly improved objective complete response rate (35.4%, n=48, vs 11.5%, n=26), and median overall survival (8.2 vs 4.5 months, HR=0.88) compared to low dose cytosine arabinoside in elderly patients with acute myeloid leukemia (PMID: 23605952).||23605952|
|Unknown unknown||breast cancer||not applicable||Barasertib||Preclinical - Cell culture||Actionable||In a preclinical study, Barasertib (AZD1152) treatment disrupted cell cycle progression and inhibited growth of breast cancer cell lines in culture, with preferential inhibition of aromatase inhibitor-resistant cell lines (PMID: 25667100).||25667100|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|