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Therapy Name Camizestrant
Synonyms
Therapy Description

Camizestrant (AZD9833) is a selective degrader of estrogen receptor, which leads to growth inhibition of ER-positive tumors (Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 1024-1024).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Camizestrant AZD-9833|AZD9 833|AZD9833|AZ-14066724 Hormone - Anti-estrogens 25 Camizestrant (AZD9833) is a selective degrader of estrogen receptor, which leads to growth inhibition of ER-positive tumors (Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 1024-1024).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05774951 Phase III Tamoxifen Exemestane Anastrozole Letrozole Camizestrant A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy (CAMBRIA-1) Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS 28
NCT04214288 Phase II Camizestrant Fulvestrant A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer (SERENA-2) Active, not recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL 8
NCT03616587 Phase I Camizestrant Camizestrant + Palbociclib Camizestrant + Everolimus Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer. (SERENA-1) Active, not recruiting USA | GBR | ESP 0
NCT04588298 Phase II Camizestrant A Study to Investigate the Biological Effects of AZD9833 in Women With ER-positive, HER2 Negative Primary Breast Cancer (SERENA-3) Completed GBR 2


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