Therapy Detail

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Therapy Name BC8-B10 + Cyclophosphamide + Fludarabine
Synonyms
Therapy Description

BC8-B10 is a radioimmunoconjugate that contains anti-CD45 monoclonal antibody BC8 with its lysine side groups conjugated with decoborate and labeled with Astatine (NCI Drug Dictionary). BC8-B10 prolongs survival of mice with disseminated murine leukemia in conjugation with bone marrow transplant (PMID: 23471305).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BC8-B10 astatine At 211 MAb BC8-B10|At 211 anti-CD45 BC8-B10|At 211 MAb BC8-B10 BC8-B10 is a radioimmunoconjugate that contains anti-CD45 monoclonal antibody BC8 with its lysine side groups conjugated with decoborate and labeled with Astatine (NCI Drug Dictionary).
Cyclophosphamide Cytoxan CPM Chemotherapy - Alkylating 14 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).
Fludarabine Fludara FAMP|Fludarabine phosphate Flurdara (fludarabine) is converted to 2-fluoro-ara-ATP intracellularly, which potentially inhibits DNA polymerase alpha, ribonucleotide reductase and DNA primase, leading to decreased DNA synthesis and reduced tumor growth (NCI Drug Dictionary)

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status
NCT03670966 Phase Ib/II BC8-B10 + Cyclophosphamide + Fludarabine Cyclophosphamide + Filgrastim + Mycophenolate mofetil + Sirolimus + Tacrolimus 211At-BC8-B10 and Donor Stem Cell Transplant in Treating Relapsed or Refractory AML, ALL, or Myelodysplastic Syndrome Recruiting


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