Therapy Detail
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| Therapy Name | Camrelizumab + Rivoceranib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Camrelizumab | SHR-1210|INCSHR-1210 | Immune Checkpoint Inhibitor 98 PD-L1/PD-1 antibody 68 | Camrelizumab (SHR-1210) is an antibody that targets PD-1 (PDCD1) and inhibits binding of PD-L1 (CD274) and PD-L2 (PDCD1LG2), potentially resulting in activation of anti-tumor immune response and decreased tumor growth (PMID: 29358502, PMID: 32623573, PMID: 32581041). | |
| Rivoceranib | YN968D1|Apatinib | KIT Inhibitor 51 RET Inhibitor 39 SRC Inhibitor 29 VEGFR2 Inhibitor 35 | Rivoceranib (apatinib) is an inhibitor of receptor tyrosine kinases, including KDR (VEGFR2), RET, c-KIT, Src, and PDGFRa, which may result in reduced cell proliferation and inhibition of tumor growth (PMID: 21443688, PMID: 32669874). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| Unknown unknown | stomach cancer | not applicable | Camrelizumab + Rivoceranib | Phase Ib/II | Actionable | In a Phase Ib trial, combined Camrelizumab (SHR-1210) and Apatinib (YN968D1) treatment resulted in an overall response rate of 17.4% (4/23), a disease control rate of 78.3% (18/23), a median progression-free survival (PFS) of 2.9 months, and an overall survival of 11.4 months in evaluable patients with gastric or gastroesophageal junction cancer (PMID: 30348638; NCT02942329). | 30348638 |
| Unknown unknown | gastroesophageal junction adenocarcinoma | not applicable | Camrelizumab + Rivoceranib | Phase Ib/II | Actionable | In a Phase Ib trial, combined Camrelizumab (SHR-1210) and Apatinib (YN968D1) treatment resulted in an overall response rate of 17.4% (4/23), a disease control rate of 78.3% (18/23), a median progression-free survival (PFS) of 2.9 months, and an overall survival of 11.4 months in evaluable patients with gastric or gastroesophageal junction cancer (PMID: 30348638; NCT02942329). | 30348638 |
| STK11 mutant | lung non-squamous non-small cell carcinoma | predicted - sensitive | Camrelizumab + Rivoceranib | Phase Ib/II | Emerging | In a Phase Ib/II trial, non-squamous NSCLC patients harboring STK11 and/or KEAP1 mutations (n=14) demonstrated an improved 12-month survival rate (85.1% vs 53.1%; p=0.01), and a trend towards improved objective response rate (42.9% vs 28.1%; p=0.33), disease control rate (92.9% vs 65.6%, p=0.053), and median progression-free survival (9.4 vs 5.3 months; p=0.64) compared to wild-type STK11/KEAP1 patients (n=32) treated with Camrelizumab (SHR-1210) plus Rivoceranib (apatinib) (PMID: 33323401; NCT03083041). | 33323401 |
| Unknown unknown | lung non-squamous non-small cell carcinoma | not applicable | Camrelizumab + Rivoceranib | Phase Ib/II | Actionable | In a Phase Ib/II trial, Camrelizumab (SHR-1210) plus Rivoceranib (apatinib) demonstrated safety and resulted in a 30.9% (29/94; one complete, 28 partial responses) objective response rate, 81.9% (77/94) disease control rate, 52.1% (49/94; disease control lasting 24 weeks or more) clinical benefit response rate, median progression-free survival of 5.7 months, and median overall survival of 15.5 months in evaluable patients with non-squamous NSCLC who received prior chemotherapy (PMID: 33323401; NCT03083041). | 33323401 |
| Unknown unknown | hepatocellular carcinoma | not applicable | Camrelizumab + Rivoceranib | Phase Ib/II | Actionable | In a Phase Ib trial, combined Camrelizumab (SHR-1210) and Apatinib (YN968D1) treatment resulted in an overall response rate of 50% (8/16), a disease control rate of 93.8% (15/16, stable disease or better), a median progression-free survival (PFS) of 5.8 months, and a 9-month PFS rate of 41.0% in evaluable patients with advanced hepatocellular carcinoma (PMID: 30348638; NCT02942329). | 30348638 |
| Unknown unknown | hepatocellular carcinoma | not applicable | Camrelizumab + Rivoceranib | Phase II | Actionable | In a Phase II trial (RESCUE), combined Camrelizumab (SHR-1210) and Rivoceranib (apatinib) treatment resulted in an objective response rate (ORR) of 34.3% (24/70), disease control rate (DCR) of 77.1% (54/70), and median progression-free survival (mPFS) of 5.7 months in previously untreated advanced hepatocellular carcinoma patients, and patients given this combination as second-line therapy demonstrated an ORR of 22.5% (27/120), DCR of 75.8% (91/120), and mPFS of 5.5 months (PMID: 33087333; NCT03463876). | 33087333 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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