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Therapy Name NMS-P088
Synonyms
Therapy Description

NMS-P088 inhibits FLT3, KIT, and CSF1R with activity against FLT3 F691L, potentially leading to antitumor activity (Cancer Res (2023) 83 (8_Supplement): CT025).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NMS-P088 NMS 03592088|NMS-03592088|NMS03592088|NMS P088|NMSP088 CSF1R Inhibitor 28 FLT3 Inhibitor 69 KIT Inhibitor 57 NMS-P088 inhibits FLT3, KIT, and CSF1R with activity against FLT3 F691L, potentially leading to antitumor activity (Cancer Res (2023) 83 (8_Supplement): CT025).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CSF1R positive chronic myelomonocytic leukemia predicted - sensitive NMS-P088 Preclinical - Patient cell culture Actionable In a preclinical study, NMS-P088 inhibited proliferation of Csf1r-expressing blasts derived from chronic myelomonocytic leukemia patients (Proceedings of the American Association for Cancer Research, Vol 60, Mar 2019, Abstract #1324). detail...
FLT3 act mut acute myeloid leukemia predicted - sensitive NMS-P088 Phase I Actionable In a Phase I trial, NMS-P088 demonstrated manageable safety and preliminary efficacy with responses in 5 of 12 patients with acute myeloid leukemia harboring FLT3 mutations (Cancer Res (2023) 83 (8_Supplement): CT025; NCT03922100). detail...

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03922100 Phase Ib/II NMS-P088 Study of NMS-03592088 in Patients With Relapsed or Refractory AML or CMML Recruiting ITA | FRA | ESP 0


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