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|Therapy Name||CC-95251 + Cetuximab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CC-95251||CC95251|CC 95251||CC-95251 is a monoclonal antibody directed against signal-regulatory protein alpha (SIRPA), which interferes with SIRPA-CD47 interaction, potentially resulting in increased immune response, leading to anti-tumor activity (Blood (2021) 138 (Supplement 1): 2493).|
|Cetuximab||Erbitux||IMC-C225||EGFR Antibody 45||Erbitux (cetuximab) is a monoclonal antibody directed against EGFR, which inhibits signal transduction and cell proliferation (PMID: 28695301). Erbitux (cetuximab) is FDA approved for use in head and neck squamous cell carcinoma and KRAS wild-type, EGFR positive colorectal cancer (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03783403||Phase I||CC-95251 CC-95251 + Cetuximab||A Study of CC-95251, a Monoclonal Antibody Directed Against SIRP?, With Cetuximab in Subjects With Advanced Solid Cancers||Active, not recruiting||USA | ITA | FRA | ESP | CAN||3|