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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MTI-31||LXI-15029||mTOR Inhibitor 51||MTI-31 (LXI-15029) inhibits mTORC1/2, potentially resulting in decreased tumor cell proliferation and tumor growth (PMID: 30796032).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EML4 - ALK||lung non-small cell carcinoma||sensitive||MTI-31||Preclinical - Cell line xenograft||Actionable||In a preclinical study, MTI-31 inhibited proliferation and migration and increased PD-L1 degradation in a non-small cell lung cancer cell line harboring EML4-ALK in culture, and inhibited tumor growth in xenograft models (PMID: 30796032).||30796032|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|