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|Therapy Name||alphaDC1 + Celecoxib + Interferon alpha-2b + Rintatolimod|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Celecoxib||Celebra||Celebra (celecoxib) is a COX-2 inhibitor FDA approved as an anti-inflammatory agent and for colorectal polyp reduction (FDA.gov) and also promotes apoptosis of tumor cells (PMID: 17909047).|
|Interferon alpha-2b||Intron A||Alfatronol|Alfatronol|interferon alpha-2b|Sch 30500|
|Rintatolimod||Ampligen|Atvogen|Poly(I).Poly(c12,U)||Rintatolimod is a synthetic dsRNA molecule that activates TLR3 and other interferon-induced proteins, which may result in increased anti-tumor immune response (PMID: 27045557, PMID: 19200817).|
|alphaDC1||alpha-type-1-polarized DC|Alpha-type-1 Polarized Dendritic Cells||alphaDC1 is a polarized DC1 vaccine comprising autologous dendritic cells that is matured by treating with chemokines, potentially resulting in enhanced cytokine production and anti-tumor immune response against tumor cells (PMID: 15342370).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT04093323||Phase II||alphaDC1 + Celecoxib + Interferon alpha-2b + Rintatolimod Ipilimumab unspecified PD-L1 antibody unspecified PD-1 antibody||Polarized Dendritic Cell (aDC1) Vaccine, Interferon Alpha-2, Rintalolimid, and Celecoxib for the Treatment of HLA-A2+ Refractory Melanoma||Not yet recruiting|