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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CDKI-73||CDK1 Inhibitor 13 CDK2 Inhibitor 19 CDK9 Inhibitor 16||CDKI-73 is a kinase inhibitor that blocks CDK9, CDK1, and CDK2 activity, which may lead to apoptotic activity and inhibition of cell proliferation and tumor growth (PMID: 30194564, PMID: 24495868).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KMT2A fusion||acute myeloid leukemia||sensitive||CDKI-73||Preclinical - Cell line xenograft||Actionable||In a preclinical study, CDKI-73 treatment inhibited Cdk9 kinase activity and viability, and induced apoptosis in acute myeloid leukemia cell lines harboring KMT2A fusions in culture, and inhibited tumor growth and induced regression in a cell line xenograft model (PMID: 30194564).||30194564|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|