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|Therapy Name||Cyclophosphamide + Fludarabine + NEXI-001 T Cells|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Cyclophosphamide||Cytoxan||CPM||Chemotherapy - Alkylating 16||Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).|
|Fludarabine||Fludara||FAMP|Fludarabine phosphate||Flurdara (fludarabine) is converted to 2-fluoro-ara-ATP intracellularly, which potentially inhibits DNA polymerase alpha, ribonucleotide reductase and DNA primase, leading to decreased DNA synthesis and reduced tumor growth (NCI Drug Dictionary)|
|NEXI-001 T Cells||NEXI001|NEXI 1001||NEXI-001 T Cells consists of allogeneic CD8+ T cells targeting several undisclosed leukemia associated antigens (NCI Thesaurus).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04284228||Phase Ib/II||Cyclophosphamide + Fludarabine + NEXI-001 T Cells||Antigen-specific T Cell Therapy for AML or MDS Patients With Relapsed Disease After Allo-HCT||Recruiting||USA||0|