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Therapy Name | H3.3K27M peptide vaccine + Montanide ISA 51 + Poly ICLC + Tetanus Toxoid peptide |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
H3.3K27M peptide vaccine | H3.3K27M-specific Peptide Vaccine | H3.3K27M peptide vaccine is vaccine based on histone 3 variant 3 (H3.3) harboring a K27M mutation (also referred as K28M), which potentially induces anti-tumor immune response against H3.3 K27M (K28M)-expressing tumor cells (Neuro-Oncology, Vol.21, suppl_6, Abs nr: PDCT-17 (LTBK-11)). | ||
Montanide ISA 51 | ||||
Poly ICLC | Hiltonol | Hiltonol (poly ICLC) is a synthetic double stranded RNA complex, which induces interferon production and stimulates anti-tumor immune response (PMID: 22126373). | ||
Tetanus Toxoid peptide |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT02960230 | Phase Ib/II | H3.3K27M peptide vaccine + Montanide ISA 51 + Nivolumab + Poly ICLC + Tetanus Toxoid peptide H3.3K27M peptide vaccine + Montanide ISA 51 + Poly ICLC + Tetanus Toxoid peptide | H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas | Completed | USA | 1 |