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Therapy Name Anti-CD19CAR-CD28-CD3zeta-EGFRt T cells
Synonyms
Therapy Description

Anti-CD19CAR-CD28-CD3zeta-EGFRt T cells consist of a defined proportion of CD4 and CD8 positive autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing an anti-CD19 fragment linked to the CD28 and CD3zeta signaling domain and a truncated human epidermal growth factor receptor (EGFRt), which has potential cytotoxic activity against CD19-expressing tumor cells (NCI Thesaurus).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Anti-CD19CAR-CD28-CD3zeta-EGFRt T cells Anti-CD19CAR-CD28-CD3zeta-EGFRt T cells consist of a defined proportion of CD4 and CD8 positive autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing an anti-CD19 fragment linked to the CD28 and CD3zeta signaling domain and a truncated human epidermal growth factor receptor (EGFRt), which has potential cytotoxic activity against CD19-expressing tumor cells (NCI Thesaurus).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02028455 Phase Ib/II Anti-CD19CAR-CD28-CD3zeta-EGFRt T cells A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia Active, not recruiting USA 0
NCT05625594 Phase I Anti-CD19CAR-CD28-CD3zeta-EGFRt T cells Cyclophosphamide + Fludarabine Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes) for the Treatment of Primary Central Nervous System Lymphoma Recruiting USA 0


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