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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AMG 900||AMG900|AMG-900||AURK Inhibitor (Pan) 12||AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases (PMID: 25367255, PMID: 32138169).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|TP53 inact mut||breast cancer||sensitive||AMG 900||Preclinical||Actionable||In a preclinical study, breast cancer cell lines with TP53 loss of function mutations had more pronounced apoptosis after treatment with AMG 900 in culture (PMID: 24091768).||24091768|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT00858377||Phase I||AMG 900||A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors||Completed||USA||1|