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ID DOID:3948
Name adrenocortical carcinoma
Definition An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer endocrine gland cancer adrenal gland cancer adrenal cortex cancer adrenocortical carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
FGFR1 amp Derazantinib adrenocortical carcinoma sensitive detail...
Unknown unknown Avelumab adrenocortical carcinoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01898715 Phase I ATR-101 Phase 1 Study of ATR-101 in Subjects With Advanced Adrenocortical Carcinoma Completed
NCT02720484 Phase II Nivolumab Nivolumab in Treating Patients With Metastatic Adrenocortical Cancer Terminated
NCT02721732 Phase II Pembrolizumab Study for the Evaluation of Efficacy of Pembrolizumab (MK-3475) in Patients With Rare Tumors Recruiting
NCT03333616 Phase II Ipilimumab + Nivolumab Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors Recruiting
NCT03370718 Phase II Cabozantinib Cabozantinib in Unresectable/Metastatic Adrenocortical Carcinoma Recruiting
NCT04187404 Phase Ib/II EO2401 + Nivolumab A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma (Spencer) Recruiting
NCT04373265 Phase I Pembrolizumab + Relacorilant Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma With Excess Glucocorticoid Production Not yet recruiting