Disease Detail

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
MAP2K1 Q56P Cobimetinib Erdheim-Chester disease predicted - sensitive detail...
BRAF V600E Vemurafenib Erdheim-Chester disease sensitive detail...
BRAF V600E Dabrafenib Erdheim-Chester disease sensitive detail...
ALK fusion Crizotinib Erdheim-Chester disease sensitive detail...
PIK3CA mutant Sirolimus Erdheim-Chester disease sensitive detail...
PIK3CA mutant Everolimus Erdheim-Chester disease sensitive detail...
RET fusion Selpercatinib Erdheim-Chester disease sensitive detail...
NRAS mutant Cobimetinib Erdheim-Chester disease sensitive detail...
MAP2K1 mutant Cobimetinib Erdheim-Chester disease sensitive detail...
PIK3CA mutant Cobimetinib Erdheim-Chester disease sensitive detail...
PIK3CA mutant Trametinib Erdheim-Chester disease sensitive detail...
MAP2K1 mutant Trametinib Erdheim-Chester disease sensitive detail...
NRAS mutant Trametinib Erdheim-Chester disease sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04079179 Phase II Cobimetinib Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders (NACHO COBI) Recruiting USA 0
NCT04198818 Phase Ib/II HH2710 A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patient With Advanced Tumors Recruiting USA 1