Disease Detail


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ID DOID:50751
Name T-cell large granular lymphocyte leukemia
Definition A T-cell acute lymphocytic leukemia that exhibits an unexplained, chronic (greater than 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia lymphoid leukemia acute leukemia acute lymphoblastic leukemia T-cell acute lymphoblastic leukemia T-cell large granular lymphocyte leukemia


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02512497 Phase I Romidepsin Busulfan + Fludarabine + Romidepsin Romidepsin Maintenance After Allogeneic Stem Cell Transplantation Unknown status USA 0
NCT03239392 Phase Ib/II BNZ-1 A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL Completed USA 0
NCT03829540 Phase I CD4CAR CD4CAR for CD4+ Leukemia and Lymphoma Recruiting USA 0
NCT05010005 Phase I Duvelisib + Ruxolitinib A Study of Ruxolitinib and Duvelisib in People With Lymphoma Active, not recruiting USA 0
NCT05225584 Phase I KT-333 Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors Recruiting USA 0
NCT05316116 Phase I Siltuximab Siltuximab in Large Granular Lymphocytic Leukemia (LGLL) Recruiting USA 0
NCT05475925 Phase Ib/II DR-01 A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas Recruiting USA | FRA | ESP | AUS 0
NCT05532722 Phase Ib/II ABC008 ABC008 in Subjects With T-cell Large Granular Lymphocytic Leukemia (T-LGLL) Recruiting USA 0
NCT05592015 Phase II Ruxolitinib Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia Recruiting USA 0