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ID | DOID:5525 |
Name | anal squamous cell carcinoma |
Definition | An anal carcinoma that arises near the squamocolumnar junction. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer intestinal cancer large intestine cancer anus cancer anal carcinoma anal squamous cell carcinoma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT00316888 | Phase II | Cetuximab + Cisplatin + Fluorouracil + Radiotherapy | Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Stage I, Stage II, or Stage III Anal Cancer | Completed | USA | 0 |
NCT03212469 | Phase Ib/II | Durvalumab + Tremelimumab | A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic Cancer (ABIMMUNE) | Active, not recruiting | FRA | 0 |
NCT03357757 | Phase II | Avelumab + Valproic acid | Avelumab With Valproic Acid in Virus-associated Cancer (LATENT) | Recruiting | CAN | 0 |
NCT03386500 | Phase I | BMX-001 | Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer | Recruiting | USA | 0 |
NCT03519295 | Phase II | Cisplatin + Docetaxel + Fluorouracil Atezolizumab + Cisplatin + Docetaxel + Fluorouracil | A Study of mDCF in Combination or Not With Atezolizumab in Advanced Squamous Cell Anal Carcinoma (SCARCE) | Unknown status | FRA | 0 |
NCT03946358 | Phase II | Atezolizumab + UCPVax | Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL) (VolATIL) | Active, not recruiting | FRA | 0 |
NCT04046133 | Phase I | Pembrolizumab | Phase 1b/II Trial of Pembrolizumab Plus IMRT in Stage III/IV Carcinoma of Anus (CORINTH) | Unknown status | 2 | |
NCT04230759 | Phase II | Durvalumab + Fluorouracil + Mitomycin C Fluorouracil + Mitomycin C | Radiochemotherapy +/- Durvalumab for Locally-advanced Anal Carcinoma. A Multicenter, Randomized, Phase II Trial of the German Anal Cancer Study Group (RADIANCE) | Recruiting | DEU | 1 |
NCT04444921 | Phase III | Carboplatin + Paclitaxel Carboplatin + Nivolumab + Paclitaxel | Testing the Addition of Nivolumab to Chemotherapy for Patients With Metastatic Anal Cancer | Recruiting | USA | 0 |
NCT04450901 | Phase I | YBL-006 | Dose Escalation/Dose Expansion Study of YBL-006 in Patients With Advanced Solid Tumors | Active, not recruiting | 3 | |
NCT04472429 | Phase III | Carboplatin + Paclitaxel Carboplatin + Paclitaxel + Retifanlimab | Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2). | Recruiting | USA | ITA | FRA | ESP | DEU | BEL | 7 |
NCT04536922 | Phase II | Aldesleukin + Cyclophosphamide + Fludarabine + iTCR-transduced PBL + Pembrolizumab | Single Patient Protocol: A Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizu... | Withdrawn | USA | 0 |
NCT04929028 | Phase II | Capecitabine + Mitomycin C Nivolumab Fluorouracil + Mitomycin C | Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer | Recruiting | USA | 0 |
NCT05544929 | Phase I | KFA115 + Tislelizumab KFA115 | A Study of Safety and Efficacy of KFA115 Alone and KFA115 in Combination With Tislelizumab in Patients With Select Advanced Cancers | Recruiting | CAN | 3 |