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|Definition||A malignant astrocytoma that is characterized as a low grade astrocytoma and has_material_basis_in neoplastic astrocytes.|
|Path||disease disease of cellular proliferation cancer cell type cancer high grade glioma malignant astrocytoma fibrillary astrocytoma|
|Molecular Profile||Therapy||Indication/Tumor Type||Response Type||Profile Response Detail|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT01734512||Phase II||Everolimus||PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children||Active, not recruiting||USA||0|
|NCT01837862||Phase Ib/II||Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole||A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas||Recruiting||USA||0|
|NCT02607124||Phase Ib/II||Ribociclib||Administration of Ribociclib Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)||Terminated||USA||0|
|NCT03355794||Phase I||Everolimus + Ribociclib||A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)||Active, not recruiting||USA||0|
|NCT04047303||Phase I||CC-90010||CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma||Active, not recruiting||USA | ESP||0|
|NCT04541082||Phase I||ONC206||Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms||Recruiting||USA||0|