Disease Detail


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ID DOID:3069
Name astrocytoma
Definition A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord.
Source DiseaseOntology.org
Alt Ids DOID:4861
Path disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer astrocytoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Veliparib astrocytoma no benefit detail...
Unknown unknown Olaparib astrocytoma not applicable detail...
Unknown unknown Niraparib astrocytoma not applicable detail...
Unknown unknown Niraparib + Radiotherapy astrocytoma not applicable detail...
Unknown unknown Dactolisib + Everolimus astrocytoma not applicable detail...
IDH1 mutant N/A astrocytoma not applicable detail...
ATRX loss IDH1 mut N/A astrocytoma not applicable detail...
ATRX loss IDH2 mut N/A astrocytoma not applicable detail...
IDH2 mutant N/A astrocytoma not applicable detail...
Unknown unknown Perifosine astrocytoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00301418 Phase Ib/II Erlotinib Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma Completed USA 0
NCT00492687 Phase II Carboplatin Temozolomide Tamoxifen Radiation Therapy, Temozolomide, Tamoxifen, and Carboplatin in Treating Patients With Malignant Gliomas Unknown status USA 0
NCT00906516 Phase II 81C6 + Bevacizumab Neuradiab Combined With Bevacizumab (Avastin) Therapy in Patients With Recurrent Glioblastoma Multiforme Unknown status USA 0
NCT00968240 Phase I Bevacizumab Super-Selective Intraarterial Intracranial Infusion of Avastin (Bevacizumab) Completed USA 0
NCT01052363 Phase I Bevacizumab + Fosbretabulin OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade Gliomas Withdrawn USA 0
NCT01130077 Phase I Poly ICLC A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction With Poly-ICLC in Pediatric Gliomas Recruiting USA 0
NCT01140568 Phase II Nilotinib Study of Platelet Derived Growth Factor Receptor (PDGFR) in Recurrent Malignant Gliomas Completed USA 0
NCT01188096 Phase II Poly ICLC A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas Unknown status USA 0
NCT01238237 Phase I Cetuximab Super-Selective Intraarterial Cerebral Infusion of Cetuximab for the Treatment of Recurrent Glioblastoma Multiforme and Anaplastic Astrocytoma Completed USA 0
NCT01266031 Phase Ib/II Bevacizumab + Vorinostat Bevacizumab Bevacizumab Versus Bevacizumab Plus Vorinostat in Adults With Recurrent Glioblastoma Completed USA 0
NCT01269853 Phase Ib/II Bevacizumab Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA Recruiting USA 0
NCT01331135 Phase I Sirolimus Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors Completed USA 0
NCT01339039 Phase I Bevacizumab + Plerixafor Plerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma Terminated USA 0
NCT01386710 Phase Ib/II Bevacizumab + Carboplatin Repeated Super-selective Intraarterial Cerebral Infusion Of Bevacizumab Plus Carboplatin For Treatment Of Relapsed/Refractory GBM And Anaplastic Astrocytoma Suspended USA 0
NCT01392209 Phase I Bevacizumab Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma Completed USA 0
NCT01403610 Phase II Bevacizumab + Evofosfamide Evofosfamide Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab Completed USA 0
NCT01434602 Phase Ib/II Everolimus + Sorafenib Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas Active, not recruiting USA 0
NCT01607905 Phase I Selinexor Safety Study of the Selective Inhibitor of Nuclear Export (SINE) KPT-330 in Patients With Advanced or Metastatic Solid Tumor Cancer Completed USA | CAN 1
NCT01721577 Phase Ib/II AXL1717 Phase I/II Trial of Safety and Anti-tumor Efficacy of AXL1717(Picropodophyllin) in the Treatment of Recurrent Malignant Astrocytomas Unknown status USA 0
NCT01734512 Phase II Everolimus PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children Active, not recruiting USA 0
NCT01884740 Phase Ib/II Bevacizumab + Cetuximab Phase I/II Trial Of Super-Selective Intraarterial Infusion Of Erbitux and Bevacizumab For Treatment Of Relapsed/Refractory Intracranial Glioma In Patients Under 22 Years Of Age Recruiting USA 0
NCT01891747 Phase I Bevacizumab + Temozolomide A Phase I Study of High-dose L-methylfolate in Combination With Temozolomide and Bevacizumab in Recurrent High Grade Glioma Active, not recruiting USA 0
NCT01999270 Phase I Bevacizumab + Irinotecan Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed USA 0
NCT02100891 Phase II Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors Active, not recruiting USA 0
NCT02101905 Phase I Lapatinib Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma Active, not recruiting USA 0
NCT02238496 Phase II Perifosine + Temsirolimus Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas Active, not recruiting USA 0
NCT02372006 Phase Ib/II Afatinib Trial of Afatinib in Pediatric Tumours Completed USA | CAN 10
NCT02423525 Phase I Afatinib Safety Study of Afatinib for Brain Cancer Active, not recruiting USA 0
NCT02490930 Phase I Fingolimod A Safety Study of Fingolimod With Radiation and Temozolomide in Newly Diagnosed High Grade Glioma Completed USA 0
NCT02529072 Phase I Nivolumab Nivolumab With DC Vaccines for Recurrent Brain Tumors Completed USA 0
NCT02549833 Phase I GBM6-AD lysate protein vaccine + Poly ICLC Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma Recruiting USA 0
NCT02607124 Phase Ib/II Ribociclib Administration of Ribociclib Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) Terminated USA 0
NCT02885324 Phase II Cabozantinib Pilot Study of Cabozantinib for Recurrent or Progressive High-Grade Glioma in Children Recruiting USA 0
NCT02924038 Phase I IMA950 + Poly ICLC Varlilumab A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG) Recruiting USA 0
NCT02942264 Phase Ib/II Zotiraciclib Temozolomide + Zotiraciclib TG02 Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of TG02 Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma Completed USA 0
NCT03011671 Phase I Acetazolamide + Temozolomide Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma Suspended USA 0
NCT03032484 Phase II Bevacizumab Bevacizumab + TVB-2640 TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma Active, not recruiting USA 0
NCT03220646 Phase II Abemaciclib The Purpose of This Study is to Test Any Good and Bad Effects of a Study Drug Called Abemaciclib (LY2835219) in Patients With Recurrent Brain Tumors. Recruiting USA 0
NCT03332355 Phase I PAC-1 + Temozolomide Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2 Suspended USA 0
NCT03343197 Phase I Ivosidenib AG-881 Study of AG-120 and AG-881 in Subjects With Low Grade Glioma Active, not recruiting USA 0
NCT03514069 Phase I Ruxolitinib Ruxolitinib + Temozolomide Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma Recruiting USA 0
NCT03528642 Phase I Radiotherapy + Telaglenastat + Temozolomide CB-839 With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma Recruiting USA 0
NCT03596086 Phase Ib/II HSV-Tk + Valacyclovir HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM Recruiting USA 0
NCT03603405 Phase Ib/II HSV-Tk HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM Recruiting USA 0
NCT03605550 Phase I PTC596 A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma Recruiting USA 0
NCT03696355 Phase I GDC-0084 Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas Active, not recruiting USA 0
NCT03871257 Phase III Carboplatin + Vincristine Sulfate Selumetinib A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma Recruiting USA | CAN 0
NCT03896568 Phase I DNX-2401 Oncolytic Adenovirus DNX-2401 in Treating Patients With Recurrent High-Grade Glioma Recruiting USA 0
NCT03919071 Phase II Dabrafenib + Trametinib Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma Recruiting USA 1
NCT03975829 FDA approved Dabrafenib + Trametinib Pediatric Long-Term Follow-up and Rollover Study Recruiting USA 3
NCT04164901 Phase III AG-881 Study of AG-881 in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO) Recruiting USA | CAN 7
NCT04166409 Phase III Selumetinib Carboplatin + Vincristine Sulfate A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma Recruiting USA | CAN 0
NCT04197934 Phase I WSD0922 WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases Recruiting USA 0
NCT04576117 Phase III Selumetinib Selumetinib + Vinblastine A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma Recruiting USA 0
NCT04704154 Phase II Nivolumab + Regorafenib A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors Recruiting USA 7