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Drug Name CART22-65s cells
Trade Name
Synonyms anti-CD22 CAR T cells CART22-65s|anti-CD22 CAR 4-1BB-TCRz CART22-65s
Drug Descriptions

CART22-65s cells consist of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets CD22, and linked to 4-1BB (CD137) co-stimulatory domain and CD3 zeta chain, which potentially leads to lysis of tumor cells expressing CD22 and antitumor activity (NCI Drug Dictionary; Blood (2022) 140 (Supplement 1): 2376-2377).

DrugClasses CD22 Immune Cell Therapy 11
CAS Registry Number NA
NCIT ID C156251


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Therapy Name Drugs Efficacy Evidence Clinical Trials
CART22-65s cells CART22-65s cells 0 1
CART22-65s cells + Cyclophosphamide + Fludarabine CART22-65s cells Cyclophosphamide Fludarabine 0 0
CART22-65s cells + huCART19 CART22-65s cells huCART19 0 1

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