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| Drug Name | SKI-G-801 |
| Trade Name | |
| Synonyms | FLT3 kinase inhibitor SKI G-801|SKI G-801|G-801|G-749 HCl |
| Drug Descriptions |
SKI-G-801 is a multi-kinase inhibitor that has activity against wild-type and mutant forms of FLT3, which blocks FLT3 signaling and potentially inhibits proliferation of FLT3-overexpressing tumor cells, and has additional activity against AXL, potentially leading to decreased tumor cell metastasis, as well as MER, RET, VEGFR1, FMS, FGFR1, FGFR3, AURKB, and AURKC (NCI Drug Dictionary; Cancer Res 2019;79(13 Suppl):Abstract nr 2010). |
| DrugClasses | Aurkb Inhibitors 21 Aurkc Inhibitors 3 AXL Inhibitor 30 FGFR1 Inhibitor 28 FGFR3 Inhibitor 19 FLT3 Inhibitor 66 MERTK Inhibitor 13 RET Inhibitor 52 VEGFR1 Inhibitor 6 |
| CAS Registry Number | 1457983-33-3 |
| NCIT ID | C155773 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cytarabine + SKI-G-801 | Cytarabine SKI-G-801 | 1 | 0 |
| SKI-G-801 | SKI-G-801 | 5 | 1 |
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