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Drug Name SKI-G-801
Trade Name
Synonyms FLT3 kinase inhibitor SKI G-801|SKI G-801|G-801|G-749 HCl
Drug Descriptions

SKI-G-801 is a multi-kinase inhibitor that has activity against wild-type and mutant forms of FLT3, which blocks FLT3 signaling and potentially inhibits proliferation of FLT3-overexpressing tumor cells, and has additional activity against AXL, potentially leading to decreased tumor cell metastasis, as well as MER, RET, VEGFR1, FMS, FGFR1, FGFR3, AURKB, and AURKC (NCI Drug Dictionary; Cancer Res 2019;79(13 Suppl):Abstract nr 2010).

DrugClasses Aurkb Inhibitors 20 Aurkc Inhibitors 3 AXL Inhibitor 28 FGFR1 Inhibitor 25 FGFR3 Inhibitor 15 FLT3 Inhibitor 61 MERTK Inhibitor 13 RET Inhibitor 48 VEGFR1 Inhibitor 5
CAS Registry Number 1457983-33-3
NCIT ID C155773

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cytarabine + SKI-G-801 Cytarabine SKI-G-801 1 0
SKI-G-801 SKI-G-801 5 1


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