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Drug Name AT-101
Trade Name
Synonyms R-(-)-gossypol acetic acid|AT101
Drug Descriptions

AT-101 is a pan-BCL2 inhibitor that inhibits the anti-apoptotic proteins BCL2, BCL-XL, and MCL1, potentially resulting in increased tumor cell apoptosis and decreased cell proliferation (PMID: 26089640, PMID: 16611409, PMID: 31388792).

DrugClasses BCL2 Family Inhibitor 6
CAS Registry Number 866541-93-7
NCIT ID C78348


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AT-101 AT-101 0 1
AT-101 + Bicalutamide AT-101 Bicalutamide 0 0
AT-101 + Carboplatin + Paclitaxel AT-101 Carboplatin Paclitaxel 0 0

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