Drug Detail


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Drug Name Foretinib
Trade Name
Synonyms GSK1363089G|XL880|EXEL-2880
Drug Descriptions

Foretinib (GSK1363089) is a multi-kinase inhibitor with activity against several receptor tyrosine kinases, including MET, KDR (VEGFR2), as well as ROS1 and NTRK fusions, which may result in decreased tumor angiogenesis and growth (PMID: 19808973, PMID: 26372962, PMID: 29463555, PMID: 30501104).

DrugClasses MET Inhibitor 59 ROS1 Inhibitor 20 TrkA Receptor Inhibitor 8 TYRO3 Inhibitor 8 VEGFR2 Inhibitor 37
CAS Registry Number 849217-64-7
NCIT ID C80058


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Foretinib Foretinib 15 0
Foretinib + PLX4720 Foretinib PLX4720 0 0
Foretinib + Rucaparib Foretinib Rucaparib 0 0
Foretinib + Veliparib Foretinib Veliparib 0 0

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