Drug Detail


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Drug Name VS-5584
Trade Name
Synonyms SB-2343|SB2343|VS5584
Drug Descriptions

VS-5584 (SB-2343) inhibits mTOR kinase and all class I PI3K isoforms, disrupting phosphorylation of substrates downstream of PI3K and mTOR, thereby preventing cell proliferation and inhibiting tumor growth (PMID: 23270925, PMID: 32286946).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40
CAS Registry Number 1246560-33-7
NCIT ID C112497


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Defactinib + VS-5584 Defactinib VS-5584 0 1
VS-5584 VS-5584 5 1

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