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E7016 is an inhibitor of PARP1 and PARP2, which results in the accumulation of DNA damage, thereby potentially resulting in increased tumor cell death and increased sensitivity to DNA damaging agents (Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B185, PMID: 19147766).
|DrugClasses||PARP Inhibitor (Pan) 21|
|CAS Registry Number||902128-92-1|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|E7016 + Temozolomide||E7016 Temozolomide||0||0|