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Drug Name | Toca 511 |
Trade Name | |
Synonyms | T5.0002|Vocimagene Amiretrorepvec |
Drug Descriptions |
Vocimagene Amiretrorepvec (Toca 511) is a retroviral vector encoding yeast cytosine deaminase, which converts the prodrug flucytosine into 5-fluorouracil upon infection of tumor cells, leading to tumor cell death (PMID: 22547150, PMID: 30676111). |
DrugClasses | Chemotherapy - Antimetabolite 14 |
CAS Registry Number | 1300724-82-6 |
NCIT ID | C91734 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Toca 511 | Toca 511 | 0 | 1 |
Toca 511 + Toca FC | Toca 511 Toca FC | 0 | 3 |