Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Zalifrelimab
Trade Name
Synonyms AGEN-188AGEN1884|AGEN1884|UGN301|UGN 301|UGN-301
Drug Descriptions

Zalifrelimab (AGEN1884) is an antibody that targets CTLA-4, potentially resulting in increased anti-tumor immune response (PMID: 31395100).

DrugClasses CTLA4 Antibody 25 Immune Checkpoint Inhibitor 146
CAS Registry Number 2148321-69-9
NCIT ID C126113


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Balstilimab + Cisplatin + Gemcitabine + Zalifrelimab Balstilimab Cisplatin Gemcitabine Zalifrelimab 0 1
Balstilimab + Doxorubicin + Zalifrelimab Balstilimab Doxorubicin Zalifrelimab 0 1
Balstilimab + rHSC-DIPGVax + Zalifrelimab Balstilimab Zalifrelimab rHSC-DIPGVax 0 1
Balstilimab + Zalifrelimab Balstilimab Zalifrelimab 0 3
Gemcitabine + Nab-paclitaxel + NLM-001 + Zalifrelimab Gemcitabine NLM-001 Nab-paclitaxel Zalifrelimab 0 1
Imiquimod + Zalifrelimab Imiquimod Zalifrelimab 0 1
Zalifrelimab Zalifrelimab 0 2

Additional content available in CKB BOOST