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Drug Name Zipalertinib
Trade Name
Synonyms CLN-081|CLN 081|CLN081|TAS6417|TAS-6417
Drug Descriptions

Zipalertinib (CLN-081) is a small molecule tyrosine kinase inhibitor with selective activity against EGFR mutations including exon 20 insertions, potentially resulting in decreased Egfr signaling and growth inhibition of EGFR-mutant tumors (PMID: 29748209, PMID: 31467113).

DrugClasses EGFR Inhibitor (Pan) 61
CAS Registry Number 1661854-97-2
NCIT ID C165567

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Pemetrexed Disodium + Zipalertinib Carboplatin Pemetrexed Disodium Zipalertinib 0 1
Cisplatin + Pemetrexed Disodium + Zipalertinib Cisplatin Pemetrexed Disodium Zipalertinib 0 1
Zipalertinib Zipalertinib 0 3


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