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Drug Name L-DOS47
Trade Name
Synonyms
Drug Descriptions

L-DOS47 comprises urease linked to a monoclonal antibody that targets CEACAM6, resulting localization to tumor sites by the CEACAM6 antibody and conversion of urea to ammonia by the urease enzyme with concomitant pH increase, which potentially leads to cytoxicity in tumor cells (J Thorac Oncol, Vol 12 , Issue 1 , S1071-S1072, PMID: 28871252).

DrugClasses
CAS Registry Number NA
NCIT ID C120068

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + L-DOS47 + Pemetrexed Disodium Carboplatin L-DOS47 Pemetrexed Disodium 0 1
Doxorubicin + L-DOS47 Doxorubicin L-DOS47 0 1
L-DOS47 L-DOS47 0 0


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