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Drug Name L-DOS47
Trade Name
Synonyms L DOS47|LDOS47
Drug Descriptions

L-DOS47 comprises urease linked to a monoclonal antibody that targets CEACAM6, which targets urease to tumors, leading to local conversion of urea to ammonia and increased pH, potentially resulting in cytoxicity in tumor cells (J Thorac Oncol, Vol 12 , Issue 1, S1071-S1072, PMID: 25938892).

DrugClasses CEACAM6 Antibody 3
CAS Registry Number NA
NCIT ID C120068


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + L-DOS47 + Pemetrexed Disodium Carboplatin L-DOS47 Pemetrexed Disodium 0 1
Doxorubicin + L-DOS47 Doxorubicin L-DOS47 0 1
L-DOS47 L-DOS47 0 0

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