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Gene Symbol EML4
Synonyms C2orf2 | ELP120 | EMAP-4 | EMAPL4 | ROPP120
Gene Description EML4, echinoderm microtubule associated protein like 4, plays a role in microtubule formation (PMID: 16890222). The fusion protein of EML4-ALK results in transformation activity and is present in a small percentage of patients with non-small cell lung cancer (PMID: 17625570, PMID: 23341890).

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Molecular Profile Protein Effect Treatment Approaches
EML4 - ALK gain of function ALK Inhibitor
EML4 - ALK ALK G1269A Alectinib AZD3463 Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK L1196M Brigatinib Ceritinib Ensartinib Entrectinib Lorlatinib Repotrectinib
EML4 - ALK ALK C1156Y Alectinib Brigatinib Ensartinib Lorlatinib
EML4 - ALK ALK S1206Y Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK G1202R Brigatinib Lorlatinib
EML4 - ALK ALK I1171T Ceritinib Lorlatinib TAE684
EML4 - ALK ALK L1152R Brigatinib Lorlatinib
EML4 - ALK ALK V1180L ASP3026 Brigatinib Ceritinib Lorlatinib TAE684
EML4 - ALK ALK I1171S Lorlatinib
EML4 - ALK ALK T1151M Alectinib AZD3463 Brigatinib Crizotinib
EML4 - ALK ALK F1174L Alectinib AZD3463 Lorlatinib
EML4 - ALK ALK R1192P Alectinib AZD3463 Brigatinib Crizotinib
EML4 - ALK ALK E1210K Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK C1156Y ALK L1198F Crizotinib
EML4 - ALK ALK L1198F Brigatinib Crizotinib
EML4 - ALK ALK F1174C Brigatinib Lorlatinib
EML4 - ALK ALK F1174C ALK L1198F Crizotinib
EML4 - ALK ALK L1196M ALK L1198F
EML4 - ALK ALK L1198F ALK G1202R Crizotinib
EML4 - ALK ALK L1198F ALK G1269A Brigatinib Crizotinib
EML4 - ALK SRC pos
EML4 - ALK ALK I1171N Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK G1202del Lorlatinib
EML4 - ALK ALK D1203N Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK F1174C ALK D1203N
EML4 - ALK ALK D1203N ALK E1210K Lorlatinib
EML4 - ALK ALK S1206F Brigatinib
EML4 - ALK ALK L1152P Brigatinib
EML4 - ALK ALK T1151dup Brigatinib
EML4 - ALK ALK F1174V Alectinib Brigatinib
EML4 - ALK ALK F1245C Ceritinib
EML4 - ALK CDKN2A del FGFR1 T141R SMAD4 Q83*
EML4 - ALK ALK I1171S ALK F1174V
EML4 - ALK ALK L1196M ALK G1269A
EML4 - ALK ALK C1156Y ALK L1196M
EML4 - ALK ALK L1198P
EML4 - ALK ALK F1174V ALK G1202R
EML4 - ALK MAP2K1 K57N
EML4 - ALK ALK C1156Y ALK I1171T
EML4 - ALK ALK C1156Y ALK F1174C
EML4 - ALK ALK C1156Y ALK F1174I
EML4 - ALK ALK C1156Y ALK F1174V
EML4 - ALK ALK C1156Y ALK D1203N
EML4 - ALK ALK C1156Y ALK L1256F
EML4 - ALK ALK C1156Y ALK G1269A
EML4 - ALK ALK I1171S ALK L1196M
EML4 - ALK ALK F1174C ALK L1196M
EML4 - ALK ALK F1174L ALK L1196M
EML4 - ALK ALK F1174V ALK L1196M
EML4 - ALK ALK I1179V ALK L1196M
EML4 - ALK ALK L1196M ALK L1198H
EML4 - ALK ALK L1196M ALK L1256F
EML4 - ALK ALK F1174C ALK G1269A
EML4 - ALK ALK L1196M ALK G1202R
EML4 - ALK ALK I1171T ALK G1269A
EML4 - ALK ALK I1171N ALK G1269A
EML4 - ALK ALK S1206C ALK E1210K
EML4 - ALK ALK F1174L ALK L1198V
EML4 - ALK NOTCH1 D1533A
EML4 - ALK NOTCH1 D1538A
EML4 - ALK FGFR1 amp
EML4 - ALK GNAS amp
EML4 - ALK HRAS amp
EML4 - ALK DDR2 amp
EML4 - ALK ALK F1174L ALK G1269A
EML4 - ALK ALK F1174L ALK D1203N ALK G1269A
EML4 - ALK ALK E1303K
EML4 - ALK ALK L1256F
EML4 - ALK ALK E1154K ALK G1202R ALK I1268V
EML4 - ALK ALK T1151M ALK C1156Y ALK F1174L ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK F1174L ALK G1202R
EML4 - ALK ALK L1196M ALK D1203N
EML4 - NTRK3 gain of function Larotrectinib
EML4 wild-type no effect